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Symbol Name ID |
Mcl1
myeloid cell leukemia sequence 1 MGI:101769 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Mouse Phenotypes | immune system phenotype |
increased B cell apoptosis |
increased T cell apoptosis |
thymus hypoplasia |
decreased thymocyte number |
abnormal B cell differentiation |
absent early pro-B cells |
absent late pro-B cells |
arrested B cell differentiation |
abnormal T cell differentiation |
decreased double-negative T cell number |
abnormal double-positive T cell morphology |
decreased double-positive T cell number |
increased double-positive T cell number |
arrested T cell differentiation |
decreased basophil cell number |
increased eosinophil cell number |
decreased mast cell number |
decreased neutrophil cell number |
decreased granulocyte number |
decreased germinal center B cell number |
absent germinal center B cells |
decreased memory B cell number |
absent memory B cells |
decreased B cell number |
absent pre-B cells |
decreased CD4-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
decreased T cell number |
decreased single-positive T cell number |
decreased naive B cell number |
small spleen |
abnormal neutrophil physiology |
impaired neutrophil recruitment |
decreased IgG1 level |
abnormal CD8-positive, alpha-beta T cell physiology |
abnormal lymph node morphology |
enlarged lymph nodes |
decreased susceptibility to type I hypersensitivity reaction |
decreased inflammatory response |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||
| Mcl1tm1Yen/Mcl1tm1Yen | |||||||||||||||||||||||||||||||||||||||||
| Mcl1em1(IMPC)Mbp/Mcl1+ | |||||||||||||||||||||||||||||||||||||||||
| Mcl1tm1Dmta/Mcl1tm1Dmta Tg(Aicda-cre)9Mbu/0 (conditional) |
* | ||||||||||||||||||||||||||||||||||||||||
| Mcl1tm1Dmta/Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ (conditional) |
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| Mcl1tm1Ywh/Mcl1tm1Ywh Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
* | ||||||||||||||||||||||||||||||||||||||||
| Mcl1tm1Ywh/Mcl1tm1Ywh Tg(Lck-cre)548Jxm/0 (conditional) |
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| Mcl1tm1Ywh/Mcl1tm1Ywh Tg(Cd4-cre)1Cwi/0 (conditional) |
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| Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+ Mcl1tm1Ywh/Mcl1tm1Ywh (conditional) |
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| Mcl1tm3Sjk/Mcl1tm3Sjk Tg(Cpa3-cre)3Glli/0 (conditional) |
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| Cd19tm1(cre)Cgn/Cd19+ Mcl1tm2Sjk/Mcl1tm3Sjk (conditional) |
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| Mcl1tm1Dmta/Mcl1+ Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ (conditional) |
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| Mcl1tm1Dmta/Mcl1+ Tg(Aicda-cre)9Mbu/0 (conditional) |
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| Mcl1tm2Sjk/Mcl1tm3Sjk Tg(Lck-cre)1Cwi/0 (conditional) |
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| Mcl1tm2Sjk/Mcl1tm3Sjk Tg(Mx1-cre)1Cgn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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